Syntara Limited (ASX:SNT) Presents Interim Data from SNT-5505 Trial

Trial Update

Syntara Limited (ASX:SNT) revealed positive interim data from the Phase 2a trial evaluating SNT-5505 in combination with ruxolitinib for treating myelofibrosis during the 66th American Society of Hematology annual meeting. The findings indicate potential for SNT-5505 as a breakthrough therapy, with plans for further interim data release in the first half of 2025, and final data expected in the second half of 2025.

Clinical Significance

The trial demonstrates that SNT-5505 may not only provide symptomatic relief but also modify the disease’s progression. Results suggest the treatment improves total symptom scores and reduces spleen volume over time, showcasing a compelling differentiation from existing therapies. Gary Phillips, Chief Executive Officer, stated, “The interim phase 2a data set positions SNT-5505 on a clear clinical and regulatory pathway to commercial value.”

Financial Position

Syntara remains financially robust, having received $8.5 million in non-dilutive grant funding over the past three years. As of September 30, 2024, the company reported a proforma cash balance of A$10.4 million.

Future Outlook

Syntara’s plans include advancing SNT-5505 towards pivotal studies by mid-2025. The trial data enhances the competitive profile of SNT-5505 within the expanding market for myelofibrosis treatments, valued at over A$4.5 billion. Additionally, a high institutional ownership rate of 52% may reflect strong investor confidence in the company’s future.

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Motley Fool contributor Lianne Eastty has no position in any of the stocks mentioned. The Motley Fool Australia's parent company Motley Fool Holdings Inc. has positions in and has recommended Syntara. The Motley Fool Australia has no position in any of the stocks mentioned. The Motley Fool has a disclosure policy. This article contains general investment advice only (under AFSL 400691). Authorised by Scott Phillips.

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