Race Oncology (ASX:RAC) Activates First Australian Clinical Site for RC220 Trial
Clinical Trial Initiation
Race Oncology has activated the Southside Cancer Care Centre in Miranda, NSW, to begin enrolling patients in its Phase 1 trial of RC220 combined with doxorubicin for advanced solid tumours. The open-label trial will be conducted across multiple sites in Australia, Hong Kong, and South Korea, using ascending doses of RC220 in up to 33 patients to determine safety, tolerability, and pharmacokinetics.
Study Overview
The Phase 1 trial aims to identify the maximum tolerated combined dose of RC220 and doxorubicin, and assess effects on clinical biomarkers including m6A RNA. An interim analysis will determine the optimal dosage for an additional 20 patients, focusing on safety, tolerability, and preliminary cardioprotective and anticancer efficacy signals. The trial employs a Bayesian design for increased flexibility and speed.
Executive Comments
CEO Dr Daniel Tillett stated, “I am proud of the hard work and dedication from the Race clinical team, George Clinical and CCF in reaching this point. I look forward to soon treating the first patient with RC220 and beginning the process of advancing RC220 as a potential new treatment able to improve cancer therapy while protecting patients from the serious side effects of cancer treatment.”
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